The U.S. Commerce Department released the trade data on Friday. The U.S. trade deficit widened to $43.89 billion in October from a deficit of $42.64 billion in September. September's figure was revised down from a deficit of $40.81 billion.
Analysts had expected a trade deficit of $40.5 billion.
The rise of a deficit was driven by a drop in exports. A stronger U.S. dollar weighed on exports.
Exports fell by 1.4% in October, while imports decreased by 0.6%.